demethylation相关论文
Facile Synthesis, Characterization of Flower-Like Vanadium Pentoxide Powders and Their Photocatalyti
In this paper,V2O5 sol was firstly prepared using vanadyl sulfate as a vanadium source by modified sol-gel method at roo......
Effect of Qinghuang Powder (青黄散) Combined with Bupi Yishen Decoction (补脾益肾方) in Treating Patients wi
Objective: To explore the effect of Qinghuang Powder (QHP, 青黄散) combined with Bupi Yishen Decoction (BPYS, 补脾益肾方......
Demethylation of methylmercury in Rice(Oryza sativa L.):an evidence of rice plant against methylmerc
Mercury(Hg)is a global heavy metal pollutant that can imperil human beings health and environment seriously.The toxicity......
The influence of iron plaque on the absorption,translocation and transformation of mercury in rice(O
Iron plaque can affect the absorption and accumulation of metal(loid)s in plants1,2.However,it is still unclear whether ......
Methylmercury(CH3Hg+)bioaccumulates in food chains and is able to cross the blood – brain and placental barrier,making ......
Zebularine is a cytidine analogue which has an ability to cause DNA demethylation in plants and many other organisms whi......
To investigate the specific angiogenic microrna(miRNA)and possible mechanisms in steroidassociated osteonecrosis of the ......
Dietary compound Diosgenin inhibits proliferation of BGC-823 gastric cancer cells through demethylat
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Dietary compound Diosgenin inhibits proliferation of Oci-Ly10 diffuse large B cell lymphoma cells th
Background: DNA methylation-mediated epigenetic silencing of microRNA is a critical event during the pathogenesis of dif......
Cationic Peroxidase from Proso Millet Induces Human Colon Cancer Cell Necroptosis by Regulating Auto
Necroptosis is a caspase-independent form of regulated cell death executed by receptor interacting protein kinase 1(......
N6-methyladenosine(m6A)is a prevalent modification in mRNA that significantly impacts biological regulation and huma......
目的探讨长春新碱调控RAS相关结构域蛋白2A(RASSF2A)去甲基化对卵巢癌细胞增殖的影响。方法将卵巢癌SKOV3细胞分为不同浓度长春新......
人类基因组中DNA的5-甲基胞嘧啶(5-mC)在人类发育、衰老和疾病中起到至关重要的作用。 TET家族蛋白能够将5-mC 转化成5-羟甲基胞嘧啶......
三甲基氯硅烷和金属锂在THF中通过还原偶合反应生成六甲基二硅烷,反应后的THF和未反应的金属锂可以回收再用,并对反应有明显地促进作用,六甲......
目的:探讨地西他滨4d方案治疗骨髓增生异常综合征(MDS)的疗效及不良反应.方法:观察地西他滨4d方案(25~30 mg·m-2·d-1静脉滴注,连......
DNA甲基化作为重要的表现遗传调控现象之一,广泛地存在于原核生物和真核生物中,并且在多种生物学过程中起到非常重要的作用.近年来......
,Virion protein 16 induces demethylation of DNA integrated within chromatin in a novel mammalian cel
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Trimethoprim (TMP) is an antibiotic frequently detected in various environments.Microorganisms are the main drivers of e......
目的通过观察去甲基化药物5-Aza-Cd R对DU145前列腺癌细胞系RNF180基因的影响,探讨前列腺癌细胞系中肿瘤抑制基因RNF180失活的机制......
目的探讨去甲基化药物5-氮杂-2′脱氧胞苷(DAC)对结肠癌细胞及其表皮生长因子和卵泡抑素结构域跨膜蛋白(TMEFF2)基因表达的影响。......
目的 探讨不同浓度的甲基转移酶抑制剂5-脱氧杂氮胞苷(5-Aza-CdR)对上皮性卵巢癌细胞系ES2、SKOV3细胞生长和体外侵袭力的影响.方......
目的 观察5-氮杂-2’-脱氧胞苷( 5-Aza-dc)对恶性乳腺癌MDA-MB-231细胞Slit2启动子的去甲基化作用及细胞运动能力的影响.方法 用5......
Objective To review the emerging role of DNA methylation inhibitors in cancer therapy and make a serious reflection on t......
Nicotine to nornicotine conversion in cultivated tobacco was reviewed in four aspects, including the effecton TSNAs form......
BACKGROUND As the third most abundant element,aluminum is widespread in the environment.Previous studies have shown that......
为了研究固体碱催化剂对大豆多糖(SSPS)脱酯效果的影响,以商业高甲氧基大豆多糖(SSPS)为原料,利用固体碱MgO为催化剂,制备低酯化度......
以β,β’-二氯代二乙基胺盐酸盐为原始原料,经与对甲氧基苯胺环合反应得到1-(4-甲氧苯基)哌嗪盐酸盐,后者经37%HB与醋酐(V/V1:1)回流反应脱去甲基,得到1-(4-羟基......
探讨了几种含间氟基团苯甲醚采用不同试剂的脱甲基方法,并用硬软酸碱理论对结果作了定性解释。结果表明,氢溴酸去甲基化能力最弱,......
目的:以T淋巴细胞株Molt-4细胞为模型,探讨甲基化抑制剂5-杂氮胞苷(5-azacytidine,5-Zac)对淋巴细胞表面程序性死亡受体-1(programmed ......
目的 研究乙型肝炎病毒(HBV)rtA181T突变与核质转运蛋白α2(KPNA2)启动子去甲基化之间的关系.方法 采用RT-qPCR和亚硫酸氢盐修饰后克隆......
1-(2-甲氧基苯基)哌嗪氢溴酸盐是苯基哌嗪类抗高血压药物的一个重要中间体.以1-(2-甲氧基苯基)哌嗪氢溴酸盐为原料,经48%氢溴酸与......
骨髓增生异常综合征(MDS)又称为难治性贫血,依赖输血,高风险向急性白血病转化,严重影响患者的生活质量和生存周期。因此尽早经骨髓......
目的:探讨氮杂脱氧胞苷(5aza2dc)联合化疗药物对骨肉瘤疗效的影响.方法:5aza2dc、阿霉素(DOX)及两药联用处理人骨肉瘤OS-732细胞24......
目的:通过使用甲基转移酶抑制剂肼屈嗪(Hydralazine)作用于胃癌细胞株BGC-823,观察Hydralazine对MTS1/p16基因启动子区CpG岛甲基化、p16......
目的观察5-氮杂-2'-脱氧胞苷(5-Aza-CdR)对肺腺癌SPC-A-1细胞视黄酸受体β(RAR-β)基因甲基化状态的影响,探讨不同浓度5-Aza-CdR对RAR-......
目的探讨去甲基化制剂5-氮杂胞苷(5-azaC)干预对Eca109细胞增殖及其抑癌基因RUNX3表达的影响。方法应用MTT法来观察5-azaC对Eca109细......
赖氨酸特异性组蛋白去甲基化酶(LSDl)是一个黄素腺嘌呤二核苷酸(FAD)依赖性单胺氧化酶,它能够特异性脱去单甲基化和二甲基化H3K4和H3K9......
目的研究异硫氰酸苯己酯(PHI)对骨髓瘤U266细胞株P16基因的去甲基化作用并探讨其作用机制。方法应用半定量逆转录-聚合酶链反应检测U......
目的观察5-氮杂-2′-脱氧胞苷(5-Aza-CdR)对胃癌AGS细胞CHFR基因去甲基化的作用,并探讨其临床意义。方法分别采用BSP和RT-PCR技术检......
棉酚及其衍生物因具有多种生物学活性而被广泛应用于临床,近年来其抗肿瘤作用亦受到各国学者的广泛重视。早期研究发现棉酚抗肿瘤......
本实验对意托啡及氢化意托啡去甲基方法进行改进.采用二苯膦盐代替原氢氧化钾对( Ⅲ )或( Ⅵ )3位选择性去甲基,产品得率由原43%提......
目的: 探讨胃癌组织中 MAGE-1基因启动子 B′B区去甲基化状态及其与病理分级及临床分期的关系.方法: 取胃癌组织标本40例,另外取同......
本文以香兰素为原料,经过脱甲基反应、溴代反应,采用不同的反应条件分别制取和分离得到了3-溴-4,5-二羟基苯甲醛(1)、2,3-二溴-4,5-......
目的:通过检测microRNA-124(miR-124)在MDS患者骨髓细胞中的表达水平及在地西他滨治疗前后的表达变化,探讨miR-124在MDS发病中的作用......
本研究旨在探讨SHP-1及C-kit基因在急性白血病细胞中的表达水平及三氧化二砷(As2O3)去甲基化作用对SHP-1及C-kit表达的影响。用RT-PC......
本研究旨在探讨SHP-1及C-kit基因在急性白血病HL-60细胞中的表达情况及5-杂氮脱氧胞苷(5-azaCdR)去甲基化作用对SHP-1及C-kit表达的......
脂肪沉积是一个复杂的生物学过程,受遗传和表观遗传的调控作用。DNA甲基化和去甲基化是表观遗传修饰的重要方式,可通过与转录因子......
以短花针茅为对象,在内蒙古西部荒漠草原进行了野外人工模拟增温和施氮试验。用毛细管电泳检测技术对不同增温和施氮条件下不同花......